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李杨峰Title：副研究员/硕导 E-mail Address：yfli3@cqu.edu.cn Tel.： |
- 个人/团队介绍
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药物化员工物学团队网站：https://www.x-mol.com/groups/li_yizhou
- 学习工作经历
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2022.09-至今 太阳成集团，太阳集团tyc9728，副研究员
2020.09-2022.08 太阳成集团，药学院，准聘副教授
2017.09-2020.08 伊利诺伊大学，太阳集团tyc9728，药物化学，博士后（导师：Gregory Thatcher 教授）
2012.09-2017.07 中科院上海有机化学研究所，药物化学，博士（导师：王任小 研究员）
2008.09-2012.07 中国药科大学，太阳集团tyc9728，药学基地班，学士（导师：陆涛 教授）
- 研究领域
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药物化员工物学，基于结构的药物设计
1. 设计合成靶向溴结构域蛋白的抑制剂并用于癌症或炎症等疾病。
2. 发展针对细胞自噬过程中重要蛋白的化学探针。
3. 开发DNA兼容的化学反应并用于构建DNA编码分子库（DNA-encoded library, DEL）。
- 项目成果
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1. 国家自然科学基金青年基金，主持，2022.01-2024.12
2. 重庆市留学人员回国创业创新支持计划项目，主持，2023.07-2025.06
- 代表性文章
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1. Yangfeng Li#, Zhengnan Shen#, Kiira Ratia, Jiong Zhao, Fei Huang, Oleksii Dubrovyskyii, Divakar Indukuri, Jiqiang Fu, Omar Lozano Ramos, Gregory Thatcher*, Rui Xiong*; Structure-Guided Design and Synthesis of Pyridinone-Based Selective BET-BD1 inhibitors, J. Med. Chem. 2024, 67, 2712-2731.
2. Yangfeng Li, Jiong Zhao, Lauren Gutgesell, Zhengnan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Huiping Zhao, Fei Huang, Debra Tonetti, Gregory Thatcher*, Rui Xiong*; Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib; J. Med. Chem. 2020, 63, 7186-7210.
3. Laura Cooper#, Adam Schafer#, Yangfeng Li#,（共同一作） Han Cheng, Bani Medegan Fagla, Zhengnan Shen, Raghad Nowar, Katherine Dye, Manu Anantpadma, Robert Davey, Gregory Thatcher, Lijun Rong*, Rui Xiong*; Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors; J. Med. Chem. 2020, 63, 11085-11099.
4. Shilian Yang#, Guixian Zhao#, Yuting Gao, Yang Sun, Xiaohong Fan, Gong Zhang, Yangfeng Li*, Yizhou Li*; In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries, Chem. Sci. 2022,13, 2604-2613.
5. Xianfu Fang#, Yiting Wang#, Pengyang He, Huilin Liao, Gong Zhang, Yangfeng Li*, Yizhou Li*; Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries, Org. Lett. 2022, 24, 3291-3296.
6. Yangfeng Li, Biao Yu, Renxiao Wang*; Efficient Synthesis of Rottlerin and Its Two Subunits, Tetrahedron Lett. 2016, 57, 1856-1859.
7. Yangfeng Li, Biao Yu, Jiansong Song*, Renxiao Wang*; Efficient Synthesis of Baicalin and Its analogs, Tetrahedron Lett. 2015, 56, 3816-3819.
