XiaoYong Tong

Dr. Xiaoyong Tong received her bachelor's degree and master's degree in Medicine from Harbin Medical University and her doctor's degree in Pharmacology from Peking Union Medical College. Dr. Tong did postdoctoral training in the cardiovascular field at Georgetown University, New York University, and Boston University. From 2007 to 2014, Dr. Tong was employed as an Assistant Professor at Boston University. In 2014, Dr. Tong joined Chongqing University. Funded by NIH, the American Diabetes Association and the National Natural Science Foundation of China, Dr. Tong's research team focuses on the pathogenesis of atherosclerosis, aortic aneurysm, pulmonary vascular remodeling, and hypertension.

ACADEMIC TRAINING:

1995 MD     Harbin Medical University, Harbin, China; Medicine

1998 MS      Harbin Medical University, Harbin, China; Nutrition and Food Hygiene

2001 PhD     Peking Union Medical College, Beijing, China; Pharmacology

POSTDOCTORAL TRAINING:

2001-2002   Research Associate, Mentor, Martin Morad, Georgetown University, USA

2002-2005   Research Associate, Mentor, William A. Coetzee, New York University, USA

2005-2007   Post Doc, Mentor, Richard A. Cohen, Boston University, USA

ACADEMIC APPOINTMENTS:

2007-2011   Research Assistant Professor, Boston University, USA

2011-2014   Assistant Professor, Boston University, USA

2014-           Professor, Chongqing University, China

Atherosclerosis, aortic aneurysm, hypertension, pulmonary hypertension, diabetic retinopathy

2021-2024 Chongqing Natural Science Foundation (cstc2021jcyj-msxmX0043), PI: XY Tong, Title: Mechanism of C674 inactivation in SERCA2 promoting pulmonary vascular remodeling.

2019-2022 National Natural Science Foundation of China (81870343), PI: XY Tong, Title: Irreversible oxidation of sarco/endoplasmic reticulum calcium ATPase 2 at cysteine 674 disturbs calcium homeostasis to accelerate abdominal aortic aneurysm and the underlying mechanisms involved.

2018-2020 Fundamental Research Funds for the Central Universities (2018CDQYYX0042), PI: XY Tong, Title: The mechanism of dysfunction of SERCA2 in promoting abdominal aortic aneurysm.

2016-2019 National Natural Science Foundation of China (31571172), PI: XY Tong, Title: The relationship between endothelial Nox4-based NADPH oxidase and atherosclerosis and the potential mechanisms involved.

2016-2019 Chongqing Research Program of Basic Research and Frontier Technology (cstc2016jcyjA0407), PI: XY Tong, Title: The relationship between smooth muscle Nox4-based NADPH oxidase and atherosclerosis and the potential mechanisms involved.

2015-2017 Fundamental Research Funds for the Central Universities (0236015202008), PI: XY Tong, Title: Role of endothelial Nox4 in regulating atherosclerosis.

2014- Chongqing University "plan 100 startup fund"(0236011104413), PI: XY Tong, Title: Role of Nox4 in cardiovascular diseases.

2010-2014 R01 NIH HL31607-26A1 PI: RA Cohen, Co-Investigator: XY Tong, Title: Redox regulation of SERCA by Nitric Oxide.

2010-2012 American Diabetes Association Junior Faculty Award 7-09-JF-69 PI: XY Tong, Title: Upregulation of Nox4 by TGF beta causes vascular dysfunction in obese Zucker rat.

2009-2011 R21DK084390 PI: RA Cohen, Co-Investigator: XY Tong, Title: Nitric Oxide in Hemodialysis AV Fistula Maturation.

2006-2009 R01 NIH HL31607 25 PI: RA Cohen, Co-Investigator: XY Tong, Title: NO, SERCA and Oxidative Stress in Atherosclerosis.

2005-2010 R01 AG027080-05 PI: RA Cohen, Co-Investigator: XY Tong, T...

1.  Tong XY*, Hou X, Jourd’heuil D, Weisbrod RM, Cohen RA (2010). Upregulation of Nox4 by TGF beta1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Cir Res.107 (8):975-83.

2.  Tong XY*, Evangelista A, Cohen RA (2010). Targeting the redox regulation of SERCA in vascular physiology and disease. Curr Opin Pharmacol. 10(2):133-8.

3.  Qin ZX, Hou XY, Weisbrod RM, Cohen RA, Tong X* (2014). Nox2 mediates high fat high sucrose diet induced nitric oxide dysfunction and inflammation in smooth muscle cells. J Mol Cell Cardiol. 72:56-63.

4.  Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Silver M, Bolotina VM, Cohen RA, Tong X* (2014). Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase C674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 289(29):19907-16.

5.  Mei Y, Thompson MD, Shiraishi Y, Cohen RA, Tong X* (2014). Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. J Mol Cell Cardiol. 76: 275-282.

6.  Chen LL, Hou XY, Xiao J, Thompson MD, Kuroda J, Ago T, Sadoshima J, Tong XY* (2014). Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis. BBA Molecular Basis of Disease. 1842(12):2489-2499.

7.  Mei Y, Thompson MD, Cohen RA, Tong X* (2015). Autophagy and protein quality control in cardiometabolic diseases. BBA Molecular Basis of Disease. 1852(2):243-251.

8.  Tong X*, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA (2015). Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol.89:185-194.

9.  Tong X*, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C (2016). Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 92:30-40. 

10.  Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X (2017). Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta. 1836(6):1382-1391.

11.  Tong X*, Hou X, Wason C, Kopel T, Cohen RA, Dember LD* (2017). Smooth muscle nitric oxide responsiveness and clinical maturation of hemodialysis arteriovenous fistulae. Am J Pathol. 187(9):2095-2101.

12.  Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P*, Lee KSS, Yang J, Zeng C*, Hammock BD, Tong X* (2020). Inactivation of SERCA2 cysteine 674 increases blood pressure by induction of endoplasmic reticulum stress and soluble epoxide hydrolase. Br J Pharmacol. 177(8):1793-1805.

13.  Que Y, Shu X, Wang L, Hu P, Wang S, Xiong R, Liu J, Chen H, Tong X* (2020). Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm. J Mol Cell Cardiol. 139:213-224.  

14.  Yu W, Xiao L, Que Y, Li S, Chen L, Hu P, Xiong R, Seta F, Chen H, Tong X* (2020). Smooth muscle NADPH oxidase 4 promotes angiotensin II-induced aortic aneurysm and atherosclerosis by regulating osteopontin. Biochim Biophys Acta Mol 15.  Basis Dis. 1866(12):165912.

16.  Yu W^#, Li S^#, Wu H^#, Hu P*, Chen L, Zeng C*, Tong X*(2021). Endothelial Nox4 dysfunction aggravates atherosclerosis by inducing endoplasmic reticulum stress and soluble epoxide hydrolase. Free Radic Biol Med. 64:44-57.

17.  Que Y, Shu X, Wang L, Hu P, Wang S, Xiong R, Chen H, Tong X* (2021). Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm by downregulation of PPARγ. Br J Pharmacol. 178:2305-2323.

18.  Liu G, Wu F, Wu H, Wang Y, Jiang X, Hu P*, Tong XY* (2021). Inactivation of cysteine 674 in the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 causes retinopathy in the mouse. Exp Eye Res. 207:108559.

19.  Wang Y, Shi J*, Tong X* (2021). Cross-talk between mechanosensitive ion channels and calcium regulatory proteins in cardiovascular health and disease. Int. J. Mol. Sci. 2021, 22, 8782. 

20.  Yu W, Xu G, Chen H, Xiao L, Liu G, Hu P, Li S, Kasim V, Zeng C, Tong X* (2022). The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway. Acta Pharmaceutica Sinica B. (in press）