Yun He

Experienced and motivated scientific and managerial leader with strong entrepreneurial spirit. Led over 30 drug discovery programs and contributed to 10 clinical compounds and over a dozen preclinical candidates. Author of over 130 scientific publications in international journals, with over 7000 citations and an H-Index of 45. Therapeutic experience including infectious diseases, oncology, metabolic diseases, CNS and inflammation. Member/advisor/director/founder for a number of review committee, associations and companies.

Website: http://www.iddts.com/

Education:

1981.09-1985.06, Southwest University, B.S. in Chemistry

1985.09-1988.06, Lanzhou University, M.S., Organic Synthesis (Supervisor: Prof. Xin-Fu Pan)

1988.11-1990.06, The Chinese University of Hong Kong, Ph.D. student, Organic Synthesis (Supervisor: Prof. Henry N.C. Wong)

1990.06-1991.08, Iowa State University, M.S., Organic Synthesis (Supervisor: Richard C. Larock)

1995.09-2000.05, Scripps Research, Ph.D., Chemistry and Biological Sciences (Supervisor: Prof. K.C. Nicolaou)

Working experience:

1991.08-1995.08, Chemist, Pharmaceutical Product Division, Abbott Labs

2000.05-2002.01, Group Leader, IONIS Pharmaceuticals

2002.01-2006.10, Associate Director, Genomic Institute of Novartis Research Foundation (GNF)

2006.10-2008.08, Sr. Director and member of Roche Global Chemistry Leadership Team, Roche R&D Center (China)

2008.09-2012.08, Sr. VP and CSO, BioDuro (Beijing), a PPD company

2012.09-present, Professor, Chongqing University, China

1.Design and synthesis of novel antibacterial and anticancer drugs

2.Targeted drug delivery

3.Total synthesis and bioactivity studies of natural products

Chinese Industry and University Collaboration Promotion Award，2018

H. B. Peng, B. B. Xie, J. J. Dai, Y. W. Dai, X. F. Cen, X. H. Yang, Y. He, “GSH-Responsive Multifunctional Nanoparticles Based on Mannose-Modified Pillar[5]arene for Targeted Antibiotic Delivery against Intracellular MRSA”, Mater. Chem. Front., 2022, 6, 360-367.

B. B. Xie, Z. P. Wang, R. X. Zhang, Z. Zhang, Y. He, “A SERS Aptasensor based on Porous Au-NC Nanoballoons for Bacteria Detection”, Anal. Chim. Acta., 2022, 1190, 339175-339181. 

B. Xu, Z. P. Wang, Q. W. Liu, X. H. Yang, X. M. Li, D Huang, Y. F. Qiu, K. Y. Tam, S. L. Zhang and Y. He, Synthesis, Biological Evaluation and Structure-Activity Relationship of Novel Dichloroacetophenones Targeting Pyruvate Dehydrogenase Kinases with Potent Anticancer Activity”, Eur. J. Med. Chem., 2021, 214, 113225-113231. 

B. B. Xie, H. B. Peng, R. X. Zhang, C. H. Wang, Y. He, “A Label-Free Electrochemical Aptasensor Based on Stone-Like Gold Nanoparticles for Ultrasensitive Detection of Tetracycline”,  J. Phys. Chem. C., 2021, 125. 5678-5683.

X. H. Yang, B. B. Xie, H. B. Peng, G. M. Shi, B. Sreenivas, Y. F. Qiu, C. H. Wang, Y. He, “Mannose-modified Exosomes for Targeted Delivery of Lysostaphin and Vancomycin to Eradicate Intracellular MRSA”, J. Control. Release, 2020, 329, 454-467

S. C. Xiang, D. Huang, Q. L. He, J. Li, K. Y. Tam, S. L. Zhang, Y. He, “Development of Dual Inhibitors Targeting Pyruvate Dehydrogenase Kinases and Human Iactate Dehydrogenase A: High-throughput Virtual Screening, Synthesis and Biological Validations”, Eur. J. Med. Chem., 2020, 1, 112579-112585.

H. B. Peng, B. B. Xie, X. H. Yang, J. J. Dai, G. X. Wei, Y. He, “Pillar[5]arene-based, Dual pH and Enzyme Responsive Supramolecular Vesicles for Targeted Antibiotic Delivery Against Intracellular MRSA”, Chem. Commun., 2020, 56, 8115-8118

Q. Tang, P. Hu, H. Peng, N Zhang, Q Zheng, Y. He, “Near-Infrared Laser-Triggered, Self-immolative Smart Polymersomes for in Vivo Cancer Therapy”, Int. J. Nanomed., 2020., 15, 137-149.

N. Zhang, P Hu, Y Wang, Q. Tang, Q. Zheng, Z. Wang, Y. He, “A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Assembly Reporting Fluorescence”, ACS Sensors., 2020, 5, 319-326.

N. Zhang, Y. He, Q. Tang, Y. Wang, Q. Zheng, P. Hu, “A Mitochondrial Targeting Two-channel Responsive Fluorescence Probe for Imaging the Superoxide Radical Anion in Vitro and in Vivo”, Talanta, 2019, 194, 79-85. 

X. H. Yang, G. M. Shi, J. Guo, C. H. Wang, Y. He, “Exosome-Encapsulated Antibiotic Against Intracellular Infections of Methicillin-Resistant Staphylococcus Aureus (MRSA).” Int. J. Nanomed., 2018, 13, 8095-8104.

Z. H. Lin, X. B. Xu, S. Zhao, X. H. Yang, J. Guo, Q. Zhang, C. M. Jing, S. Chen and Y. He, “Total Synthesis and Antimicrobial Evaluation of Natural Albomycins against Clinical Pathogens.” Nat. Commun., 2018, 9, 3445.

B. Xu, Z. M. Yu, S. C. Xiang, Y. S. Li, S. L. Zhang, Y. He, “Rational Design of Mitochondria-targeted Pyruvate Dehydrogenase Kinase 1 Inhibitors with Improved Selectivity and Antiproliferative Activity.” Eur. J. Med. Chem., 2018, 155, 275-284.

N. Zhang, Z. M. Yu, X. H. Yang, P. Hu, Y. He, “Synthesis of Novel Ring-contracted Artemisinin Dimers with Potent Anticancer Activities”, Eur. J. Med. Chem., 2018, 150, 829-840.

A. Yesu, X. H. Yang, M. H. Zhou, P. R. Devi, S. L. Zhang, Z. Wang, Y. He, “Synthesis and Anticancer Activity Evaluation of Novel Azacalix[2]arene[2]pyrimidines.” Eur. J. Med. Chem., 2018, 151, 214-225.

P. R. Devi, N. Zhang, Z. M. Yu, Z. Wang, Y. He, “Total Synthesis of Kanamienamide.” J. Org. Chem., 2017, 82, 11262–11268.

B. Sreenivas, P. R. Devi, W. X. Li, C. H. Wang, J. Guo, Y. He, “A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G.” Org. Lett., 2017, 19, 4996–4999.

Q. Liu, P. Hu and Y. He, “Asymmetric Total Synthesis of Nannocystin A.” J. Org. Chem., 2017, 82, 9217–9222.

M.Q. Tang; P. Hu; Q. Zheng; N. Tirelli; X. H. Yang; Z. L. Wang; Y. F. Wang; Q. Tang; Y. He, “Polymeric Micelles with Dual Thermal and Reactive Oxygen Species (ROS)-Responsiveness for Inflammatory Cancer Cell Delivery.” J. Nanobiotechnology, 2017, 15, 39-45.

Q. Zheng, P. Hu, Q. Tang, M. Q. Tang, Z. L. Zang, P. L. Shao, Z. Wang, Y. He, “Dually Responsive Amphiphilic Block Copolymer with Oxidation-Responsiveness and Tuneable LCST Behaviours” Materials Letters, 2017, 201, 133-136.

Z. L. Zang, S. Zhao, S. Karnakanti, C. L. Liu, P. L. Shao and Y. He, “Catalytic Multisite-Selective Acetoxylation Reactions at sp2 vs sp3 C–H Bonds in Cyclic Olefins.” Org. Lett., 2016, 18, 5014–5017.

N. Qi, S. R. Allu, Z. L. Wang, Q. Liu, J. Guo, and Y. He, “Asymmetric Total Syntheses of Aetheramides and Their Stereoisomers: Stereochemical Assignment of Aetheramides.” Org. Lett., 2016, 18, 4718–4721.

R. S Reddy, C. Lagishetti, I. N. C Kiran, H. Y. You, and Y. He, “Transition-Metal-Free Cascade Synthesis of 4-Quinolones: Umpolung of Michael Acceptors via Ene Reaction with Arynes.” Org. Lett., 2016, 18, 3818–3821.

J. Guo, I. N. C Kiran, R. S Reddy, J. S. Gao, M. Q. Tang, Y. Y. Liu, and Y. He, “Synthesis of Carbazolequinones by Formal [3 + 2] Cycloaddition of Arynes and 2-Aminoquinones.” Org. Lett., 2016, 18, 2499–2502.

Y. He, P. K. Agarwal, I. N. C Kiran, R. C. Yu, B. Cao, C Zou, X. H. Zhou, H. C. Xu, B. Xu, L. Zhu, Y. Lan, K. C. Nicolaou, “Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones.” Chem. Eur. J., 2016, 22, 7696–7701.

J. C. Wong, G. Tang, X. Wu, C. Liang, Z. Zhang, L. Guo, Z. Peng, W. Zhang, X. Lin, Z. Wang, J. Mei, J. Chen, S. Pan, N. Zhang, Y. Liu, M. Zhou, L. Feng, Weili Zhao, S. Li, C. Zhang, M. Zhang, Y. Rong, T. Jin, X. Zhang, S. Ren, Ying Ji, R. Zhao, J. She, Y. Ren, C. Xu, D. Chen, J. Cai, S. Shan, D. Pan, Z. Ning, X. Lu, T. Chen, Y. He, L. Chen. "Pharmacokinetic Optimization of Class-Selective Histone Deacetylase Inhibitors and Identification of Associated Candidate Predictive Biomarkers of Hepatocellular Carcinoma Tumor Response." J. Med. Chem. 2012, 55, 8903-8925.

G. Zhang, P. Ren, N.S. Gray, T. Sim, X. Wang, Y. Liu, J. Che, W. Dong, S.S. Tian, M.L. Sandberg, T.A. Spalding, R. Romeo, M. Iskandar, Z. Wang, M.H. Seidel, D.S. Karanewsky, Y. He, “Discovery of Pyrimidine Benzimidazoles as Src-family Selective Lck Inhibitors. Part II.” Bioorg. Med. Chem. Lett. 2009, 19, 6691.

B. Wu, K. Kuhen, T. N. Nguyen, D. Ellis, B. Anaclerio, X. He, K. Yang, D. Karanewsky, H. Yin, K. Wolff, K. Bieza, J. Caldwell, Y. He, "Synthesis and Evaluation of N-Aryl Pyrrolidinones as Novel Anti-HIV-1 Agents. Part 1." Bioorg. Med. Chem. Lett., 2006, 16, 3430-3433.

Y. He, J, Yang, B. Wu, D. Robinson, K. Sprankle, P.-P. Kung, K. Lowery, V. Mohan, S. Hofstadler, E. E. Swayze, R. Griffey, “Synthesis and Evaluation of Novel Bacterial rRNA-binding Benzimidazoles by Mass Spectrometry.” Bioorg. Med. Chem. Lett., 2004, 14, 695-699.

K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, F. Roschangar, F. Sarabia, S. Ninkovic, Z. Yang, “The Olefin Metathesis Approach to Epothilone A and Its Analogs.” J. Am. Chem. Soc., 1997, 119, 7960-7973.